BioArt is an art practice in which the medium is living matter and the works of art are produced in laboratories and/or artists' studios. The tool is biotechnology, which includes such technologies as genetic engineering, tissue culture and cloning. BioArt is considered by most artists to be strictly limited to “living forms,” although there is some debate as to the stages at which matter can be considered to be alive or living. The materials used by Bioartists are cells, DNA, proteins and living tissue. Creating living beings and practicing in the life sciences brings about ethical, social and aesthetic inquiry. The phrase "BioArt" was coined by Eduardo Kac in 1997 in relation to his artwork "Time Capsule". Although it originated at the end of the 20th century through the works of pioneers like Kac and Gessert, BioArt started to be more widely practiced in the beginning of the 21st Century.